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SR-4835

SR-4835

Item no.	CS-0106031-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2387704-62-1
Similar products	2387704-62-1
Available
CAS	2387704-62-1
Purity	>98%
MWt	499.36
Formula	C21H20Cl2N10O
Solubility	DMSO : 5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60C)
Clinical Information	No Development Reported
Pathway	Apoptosis; Cell Cycle/DNA Damage
Target	Apoptosis; CDK
Biological Activity	SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC₅₀=99 nM, K_d=98 nM; CDK13: K_d=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death^[1]. In Vitro: SR-4835 (90 nM; 0.5-48 hours) suppresses ATM and RAD51 protein levels^[1]. SR-4835 inhibits CDK12/CDK13 which triggers intronic polyadenylation site cleavage and suppresses the expression of core DNA damage response proteins^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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