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5-ALA benzyl ester (hydrochloride)

5-ALA benzyl ester (hydrochloride)

Item no.	CS-0110809-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	163271-32-7
Similar products	163271-32-7
Available
Alternative Names	Benzyl-ALA (hydrochloride)
CAS	163271-32-7
Purity	>98%
MWt	257.71
Formula	C12H16ClNO3
Solubility	DMSO : 250 mg/mL (970.08 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Endogenous Metabolite
Biological Activity	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines^[1]^[2]. In Vitro: 5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480^[2]. In Vivo: Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels^[3].
Research Area	Cancer

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