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Lp-PLA2-IN-3

Lp-PLA2-IN-3

Item no.	CS-0112334-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Fatty Acid Catabolism Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2196245-16-4
Similar products	2196245-16-4
Available
CAS	2196245-16-4
Purity	>98%
MWt	467.85
Formula	C20H13ClF3N3O3S
Solubility	DMSO : >= 250 mg/mL (534.36 mM)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Phospholipase
Biological Activity	Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC₅₀ of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2)^[1]. In Vivo: Lp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the C_max, AUC_0-24h, t_1/2 and F were 0.27 ug/mL, 3.4 ug h/mL, 7.7 hours and 35.5%, respectively^[1]. Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t_1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively^[1].
Research Area	Cardiovascular Disease

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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