Artelinic acid

120020-26-0

418.48

10 mM in DMSO

Anti-infection

Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes^[1][2]. In Vivo: Artelinic acid (10 mg/kg; i.v.) has an elimination time t_1/2 of 0.37 hours, a CL of 14.99 mL/min/kg, a V_ss of 9.52 L and a AUC_0-12h of 11219 ng h/mL for dogs^[1].
Artelinic acid (10 mg/kg; intramuscular) has an elimination time t_1/2 of 6.14 hours, a CL of 14.58 mL/min/kg, a V_ss of 36.1 L and a AUC_0-12h of 96372 ng h/mL for dogs^[1].
Artelinic acid (10 mg/kg; oral) has an elimination time t_1/2 of 2.21 hours, a CL of 14.6 mL/min/kg, a V_ss of 16.2 L and a AUC_0-12h of 8839 ng h/mL for dogs^[1].