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1-Cyclohexyl-3-dodecyl urea

1-Cyclohexyl-3-dodecyl urea

Item no.	CS-0114069-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	402939-18-8
Similar products	402939-18-8
Available
Alternative Names	CDU; N-Cyclohexyl-N-dodecyl urea; NCND
CAS	402939-18-8
Purity	>98%
MWt	310.52
Formula	C19H38N2O
Solubility	Ethanol : 16.67 mg/mL (53.68 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Epoxide Hydrolase
Biological Activity	1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension^[1]. IC50 & Target: IC50: soluble epoxide hydrolase (sEH)^[1] In Vivo: 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals^[1].
Research Area	Metabolic Disease; Cardiovascular Disease

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Amount: 10mg

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