2',5'-Dideoxyadenosine

6698-26-6

235.24

DMSO : 125 mg/mL (531.37 mM; Need ultrasonic)

GPCR/G Protein; GPCR/G Protein; Neuronal Signaling

2', 5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC₅₀ of 3 uM . 2', 5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart^[1][2]. IC50 & Target: IC50: 3 uM (adenylyl cyclase)^[1] In Vitro: 2', 5'-Dideoxyadenosine (10 uM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh)^[3].
2', 5'-Dideoxyadenosine (10 uM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448^[3].
2', 5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively^[2].
In Vivo: 2', 5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K⁺ and Cl^- sparing effect of Fr-EtOAc in rats^[4].