CDDO-3P-Im

1883650-95-0

618.81

DMSO : 250 mg/mL (404.00 mM; Need ultrasonic)

Apoptosis

CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model^[1]. CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R)^[2]. In Vitro: CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM^[1].
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC₅₀ of 4.3 nM^[1].
In Vivo: CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies^[1].
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo^[1].
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice^[1].