A2ti-1

Item no.	CS-0129702-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	570390-00-0
Similar products	570390-00-0
Available
CAS	570390-00-0
Purity	>98%
MWt	382.48
Formula	C20H22N4O2S
Solubility	DMSO : 250 mg/mL (653.63 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Anti-infection
Target	Virus Protease
Biological Activity	A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC₅₀ of 24 uM^[1]. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection^[2]. IC50 & Target: IC50: 24 uM (A2t)^[1] In Vitro: A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker^[1]. A2ti-1 (100 uM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner^[2]. A2ti-1 (10, 25, 50, 75, 100 uM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner^[2].
Research Area	Infection

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 15 days

Compare

Add to wishlist

Get an offer