GLP-1(32-36)amide

1417302-71-6

570.73

DMSO : 250 mg/mL (438.04 mM; Need ultrasonic)

GPCR/G Protein

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
In Vitro: GLP-1(32-36)amide (0.1-10 uM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 uM) in INS?1 cells.
In Vivo: GLP-1(32-36)amide (1 umol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice.

GLP-1(32-36)amide (1 umol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice.

GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice.