TEI-9648

173388-21-1

426.59

10 mM in DMSO

Vitamin D Related

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1alpha, 25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1alpha, 25(OH)2D3. TEI-9648 has the potential for bone metabolism research.
In Vitro: TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1alpha, 25(OH)2D3.

TEI-9648 has consistently weaker suppressive effect than TEI-9647.

TEI-9648 can not induce cell differentiation even after treatment at 1 uM in HL-60 cell.

TEI-9648 alone can not induce activation of NBT-reducing activity or alpha-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1alpha, 25(OH)2D3 (0.1 nM) in HL-60 cells.