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Teriflunomide impurity 3

Teriflunomide impurity 3

Item no.	CS-0148567-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1011244-72-6
Similar products	1011244-72-6
Available
Alternative Names	4-Amino-N-(4-trifluoromethylphenyl)benzamide
CAS	1011244-72-6
Purity	>98%
MWt	280.25
Formula	C14H11F3N2O
Solubility	DMSO : 250 mg/mL (ultrasonic)
Clinical Information	No Development Reported
Pathway	Immunology/Inflammation
Target	COX
Biological Activity	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 uM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 uM). IC50 & Target: IC50: 30 uM (COX-1) In Vitro: Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity.

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