Daun02

290304-24-4

C41H44N2O20

DMSO : >= 100 mg/mL (113.02 mM)

Cell Cycle/DNA Damage; Antibody-drug Conjugate/ADC Related

Daun02 is converted by beta-galactosidase to Daunorubicin, which is a topoisomerase inhibitor. IC50 & Target: Topoisomerase^[1][2] In Vitro: Daun02 is a prodrug, which is converted by beta-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca²⁺)-dependent action potentials in neuroblastoma cells^[1]. Daunorubicin is a topoisomerase inhibitor^[2]. Daun02 is a good substrate for beta-galactosidase (beta-gal). The concentration of Daun02 producing 50% (EC₅₀) decrease in cell viability is 0.5 uM, 1.5 uM, and 3.5 uM for T47-D, Panc02, and MCF-7, respectively^[3]. In Vivo: Daun02 is a good substrate for beta-gal with K_m and V_max values of 0.37 mM and 8.6 umol/min/mg protein. At a concentration of 10^-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin^[3].