Toltrazuril (sulfone)

69004-04-2

457.38

DMSO : 50 mg/mL (109.32 mM; Need ultrasonic)

Anti-infection

Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry^[1][2]. IC50 & Target: Anticoccidial^[1] In Vitro: Toltrazuril sulfone inhibits development of merozoites of S. neurona^[1].
Toltrazuril sulfone inhibits development of N. caninum after approximately 48 h post-exposure^[1].
Toltrazuril sulfone exhibits inhibitory possibly by targeting different enzyme/enzyme systems in different apicomplexans^[1].
Toltrazuril sulfone (5 mg/ml; 20 hours) inhibits T. gondii replication after the second division by endodyogeny^[2].
In Vivo: Toltrazuril sulfone is effective in preventing and treating toxoplasmosis in mice^[2].