SBE-beta-CD

182410-00-0

N/A

DMSO : 5.625 mg/mL (Need ultrasonic and warming); H2O : 250 mg/mL (Need ultrasonic)

Others

SBE-beta-CD is a sulfobutylether beta-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble drugs. In Vitro: SBE-beta-CD is a chemically modified beta-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. beta-CD functioned is a solubilizer only at low concentrations, whereas SBE7-beta-CD exhibits strong solubilizing effects over a wide concentration range^[1]. In Vivo: SBE-beta-CD is a derivatized form of beta-cyclodextrin that has been developed as a safe and effective solubilizing agent for drugs being administered by parenteral and other routes (including oral). SBE-beta-CD is a cyclic carbohydrate comprised of seven glucose molecules; the resulting truncated cone-like structure being further derivatized with an average of seven sulfobutyl ether groups^[2]. The calorimetric data for the Compound 1/SBE-beta-CD complex indicates an extremely strong interaction, with an association constant of 2.3+/-(0.2)x10⁶M^-1 at 25C and 1.6+/-(0.2)x10⁶M^-1 at 37C^[3]. SBE-beta-CD alone evokes a mild cardio-depressant effect independent of cocaine treatment (p=0.0001 compared to baseline) but attenuates further cocaine-induced decreases in RPP, dP/dtmax, and dP/dtmax_abs at high cocaine concentrations. No significant effect is seen on line pressure SBE-beta-CD alleviates the most pronounced cardiac depression for RPP, dP/dtmax, and dP/dtmax_abs. This differential effect of SBE-beta-CD at low and high concentrations produces an interaction effect in the two-way ANOVA for RPP (p<0.0001), dP/dtmax (p=0.0001), and dP/dtmax_abs (p=0.0015), and prevents any overall treatment effect. Infusing SBE-beta-CD also attenuates the cardiac depression associated with cocaethylene toxicity for RPP and dP/dtmax. No differences are observed between ethanol-treated controls and cocaethylene plus SBE-beta-CD groups^[4].