Vigabatrin

68506-86-5

C6H11NO2

H2O : >= 52 mg/mL (402.60 mM)

Neuronal Signaling; Membrane Transporter/Ion Channel

Vigabatrin(gamma-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. IC50 value: Target: GABA transaminase Clinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 ug) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment.