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BML-190

BML-190

Item no.	CS-0853-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	2854-32-2
Available
Alternative Names	Indomethacin morpholinylamide; IMMA
CAS	2854-32-2
Purity	>98%
Formula	C23H23ClN2O4
MWt	426.89
Solubility	DMSO : 50 mg/mL (117.13 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein; Neuronal Signaling
Target	Cannabinoid Receptor; Cannabinoid Receptor
Biological Activity	BML-190(IMMA) is a potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 uM for CB2 and CB1 respectively). IC50 Value: 435 nM(Ki CB2) Target:CB2 receptor in vitro: BML-190 increases the accumulation of cAMP, via forskolin-stimulated mechanism in HEK-293 cells. Alternate studies suggest that BML-190 reduces the toxicity of culture supernatants to SH-SY5Y human neutroblastoma cells. Various research suggests that BML-190 is an essential tool in studying the proliferation of neuroblastoma. BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. in vivo:

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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