VX-11e

Item no.	CS-0995-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	896720-20-0
Available
CAS	896720-20-0
Purity	>98%
Formula	C24H20Cl2FN5O2
MWt	500.35
Solubility	H2O : < 0.1 mg/mL (insoluble); DMSO : >= 100 mg/mL (199.86 mM)
Clinical Information	No Development Reported
Pathway	Stem Cell/Wnt; MAPK/ERK Pathway
Target	ERK; ERK
Biological Activity	VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with K_i < 2 nM. In Vitro: VX-11e is active in the HT29 cell proliferation assay (IC₅₀=48 nM)^[1]. In Vivo: VX-11e is orally bioavailable in both rat and mice^[1]. VX-11e (50 mg/kg, p.o.) results in robust inhibition of pRSK, and inhibits tumor growth in NSG mice bearing human melanoma RPDX tumors. VX-11e with BKM120 significantly improves tumor growth inhibition^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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