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NNC 55-0396

NNC 55-0396

Item no.	CS-1240-5mg
Manufacturer	ChemScene
CASRN	357400-13-6
Amount	5mg
Category	Cardiovascular Research Myocardial Infarction Hypertension Reagents & Chemicals Arrhythmias Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	357400-13-6
Available
Alternative Names	NNC 55-0396 dihydrochloride
CAS	357400-13-6
Purity	>98%
Formula	C30H40Cl2FN3O2
MWt	564.56
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Target	Calcium Channel; Calcium Channel
Biological Activity	NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 uM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. IC50 value: 6.8 nM Target: Cav3.1 T-type channel NNC 55-0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may functions by dissolving in or passing through the plasma membrane of cells.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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