360A (iodide)

737763-37-0

C27H23I2N5O2

DMSO : 2 mg/mL (2.84 mM; Need ultrasonic)

Cell Cycle/DNA Damage; Cell Cycle/DNA Damage

360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay. IC50 & Target: IC50: 300 nM (Telomerase)^[1]
G-quadruplex^[1] In Vitro: 360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC₅₀s of 4.8 +/- 1.1 uM, 3.9 +/- 0.4 uM, 8.4 +/- 0.5 uM, >15 uM and 17.4 +/- 1.2 uM, respectively^[1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions^[2].