Ilomastat

142880-36-2

C20H28N4O4

DMSO : >= 47 mg/mL (120.99 mM)

Metabolic Enzyme/Protease

Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1). In Vitro: Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with K_is of 0.4 nM, 20 nM, 20 nM, resepctively^[1]. Ilomastat (0.1-10 nM) inhibits gelatinase A and gelatinase B produced by T-cells. Ilomastat inhibits T-cell homing^[4]. In Vivo: Ilomastat (GM6001) (400 ug/mL) inhibits corneal ulceration after severe alkali injury in animals^[2]. Ilomastat (GM6001) significantly suppresses intimal hyperplasia and intimalcollagen content. Ilomastat increases lumen area in stented arteries, shows no activity on proliferation rates in rabbit model after stenting^[3].