Mps1-IN-2

1228817-38-6

C26H36N6O3

DMSO : 14.3 mg/mL (29.75 mM; Need ultrasonic and warming)

Cell Cycle/DNA Damage; Cell Cycle/DNA Damage; Cytoskeleton

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC₅₀ and a K_d of 145 nM and 12 nM for Mps1 and a K_d of 61 nM for Plk1. IC50 & Target: IC50: 145 nM (Mps1)^[1]
Kd: 12 nM (Mps1)^[1] In Vitro: Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC₅₀ and a K_d of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with K_ds of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells^[1].