Naproxen (sodium)

26159-34-2

252.24

DMSO : 5 mg/mL (19.82 mM; Need ultrasonic); H2O : 75 mg/mL (297.34 mM; Need ultrasonic and warming)

Immunology/Inflammation; Autophagy

Naproxen sodium is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 uM, respectively in cell assay. IC50 & Target: IC50: 8.72 uM (COX-1), 5.15 uM (COX-2)^[1] In Vitro: Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC₅₀s of 2.2 ug/mL and 1.3 ug/mL, respectively^[1]. In Vivo: Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-beta levels and Smad3/4 complex formation^[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC₅₀=27, 40, 13 uM)^[3].