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UNC0224

UNC0224

Item no.	CS-2210-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1197196-48-7
Available
CAS	1197196-48-7
Purity	>98%
Formula	C26H43N7O2
MWt	485.67
Solubility	DMSO : 16.67 mg/mL (34.32 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Epigenetics
Target	Histone Methyltransferase
Biological Activity	UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in the G9a Thioglo assay. IC50 value: 15 nM [1] Target: G9a UNC0224 (Compound 8) also potently inhibited GLP with an IC50 of 20 nM and 58 nM in the Thioglo assay and and AlphaScreen, respectively. 8 was more than 1000-fold selective for G9a over SET7/9 (a H3K4 HMT) and SET8/PreSET7 (a H4K20 HMT) in Thioglo-based biochemical assays [1] [2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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