Sparfloxacin

110871-86-8

C19H22F2N4O3

H2O : < 0.1 mg/mL (insoluble); DMSO : 4 mg/mL (10.19 mM; Need ultrasonic)

Anti-infection

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity. IC50 & Target: Antibacterial^[1]. In Vitro: Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 ug/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 ug/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 ug/ml against glucose nonfermenters, 0.2 to 0.78 ug/ml against anaerobes, 0.0125 to 0.05 ug/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice^[1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis^[2].