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Nateglinide

Nateglinide

Item no.	CS-2528-100mg
Manufacturer	ChemScene
CASRN	105816-04-4
Amount	100mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Hypertension Reagents & Chemicals Arrhythmias Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	105816-04-4
Similar products	105816-04-4
Available
Alternative Names	A4166; Senaglinide
CAS	105816-04-4
Purity	>98%
MWt	317.42
Formula	C19H27NO3
Solubility	DMSO : 100 mg/mL (315.04 mM; Need ultrasonic)
Clinical Information	Launched
Pathway	Metabolic Enzyme/Protease; Membrane Transporter/Ion Channel
Target	Dipeptidyl Peptidase; Potassium Channel
Biological Activity	Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K⁺ channels in pancreatic beta-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus^[1]^[2]. In Vitro: Nateglinide inhibits typical recordings of dinitrophenol-induced K_ATP currents in a concentration-dependent manner. Nateglinide exhibits IC₅₀ values of 7.4 uM and 2.4 uM for 5 mM glucose (G5) and 16 mM (G16) glucose, respectively^{[2]^{. In Vivo: Nateglinide (50mg/kg, orally in mice) stimulates human C-peptide secretion in the humanized mice and improved postprandial glucose concentrations^{[3]^.}}}
Research Area	Metabolic Disease

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Amount: 100mg

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