Allylthiourea

109-57-9

116.18

DMSO : >= 100 mg/mL (860.73 mM)

Metabolic Enzyme/Protease; NF-kappaB; Immunology/Inflammation

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation. Target: Others Allylthiourea selectively inhibits ammonia oxidation at concentrations 8-80 uM. Allylthiourea (1 uM)inhibits ammonia oxidation by 80%. Complete inhibition is observed at an Allylthiourea concentration of 86 uM [1]. The inhibition of Allylthiourea on ammonia oxidation probably acts through chelating the copper of the ammonia monooxygenase active site. Allylthiourea is able to produce soluble methane monooxygenase (sMMO) in the presence of copper. Addition of 25 uM Allylthiourea decreases intracellular copper by 48% in Methylosinus trichosporium OB3b, allowing sMMO production at Cu/biomass ratios normally not permitting sMMO synthesis, which achieves a plateau of 320 umol naphthol formed per gram dry biomass per hour [2].