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TCS JNK 5a

TCS JNK 5a

Item no.	CS-2690-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	312917-14-9
Similar products	312917-14-9
Available
Alternative Names	JNK Inhibitor IX
CAS	312917-14-9
Purity	>98%
MWt	332.42
Formula	C20H16N2OS
Solubility	DMSO : >= 51 mg/mL (153.42 mM)
Clinical Information	No Development Reported
Pathway	MAPK/ERK Pathway; Apoptosis
Target	JNK; Apoptosis
Biological Activity	TCS JNK 5a is a potent JNK3 inhibitor with a pIC₅₀ of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC₅₀ of 6.5. IC50 & Target: pIC50: 6.7 (JNK3), 6.5 (JNK2), <5.0 (JNK1), <4.8 (p38alpha)^[1] In Vitro: TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3beta, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC₅₀<5.0) against all of them^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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