ML347

Item no.	CS-3211-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1062368-49-3
Similar products	1062368-49-3
Available
Alternative Names	LDN 193719
CAS	1062368-49-3
Purity	>98%
MWt	352.39
Formula	C22H16N4O
Solubility	DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	TGF-beta/Smad
Target	TGF-beta Receptor
Biological Activity	ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3. IC50 value: Target: ALK1/ALK2 ML347 has IC50's of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10, 800 nM, >300-fold selective over ALK3. ML347 is completely inactive against all the other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19, 700 nM). ML347 is potent in the BMP4 cell assay (152 nM).
Research Area	Cancer

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