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(R)-(-)-Rolipram

(R)-(-)-Rolipram

Item no.	CS-3246-50mg
Manufacturer	ChemScene
CASRN	85416-75-7
Amount	50mg
Category	Cardiovascular Research Thrombosis & Hemostasis Hypertension Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	85416-75-7
Available
Alternative Names	(R)-Rolipram; (-)-Rolipram
CAS	85416-75-7
Purity	>98%
Formula	C16H21NO3
MWt	275.34
Solubility	DMSO : >= 49 mg/mL (177.96 mM)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Phosphodiesterase (PDE)
Biological Activity	(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC₅₀ of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. In Vitro: The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1beta secretion in a dose-dependent manner^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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