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JNJ-40411813

JNJ-40411813

Item no.	CS-3357-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1127498-03-6
Available
Alternative Names	ADX-71149
CAS	1127498-03-6
Purity	>98%
Formula	C20H25ClN2O
MWt	344.88
Solubility	DMSO : 25 mg/mL (72.49 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	GPCR/G Protein; Neuronal Signaling
Target	mGluR; mGluR
Biological Activity	JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. IC50 value: 147 nM(EC50) Target: mGlu2R JNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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