IOX1

Item no.	CS-3370-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	5852-78-8
Available
CAS	5852-78-8
Purity	>98%
Formula	C10H7NO3
MWt	189.17
Solubility	DMSO : 13.33 mg/mL (70.47 mM; Need ultrasonic and warming)
Clinical Information	No Development Reported
Pathway	Epigenetics
Target	Histone Demethylase
Biological Activity	IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad?spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC₅₀ values of 0.6 uM, 2.3 uM, 1.8 uM, 0.1 uM and 1.4 uM, respectively^[1]. In Vitro: IOX1 (0-200 uM; 2 hours) inhibits the proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated with angiotensin II (Ang II) in a concentration-dependent manner^[2]. IOX1 (200 uM; 24 hours) blocks the cell cycle progression of angiotensin II (Ang II)-VSMCs by increasing the percentage of cells in the G0/G1 phase^[2]. IOX1 (50-200 uM; 2 hours) attenuates cyclin D1 and upregulates p21 mRNA levels in a concentration-dependent^[2]. IOX1 (50-200 uM; 2 hours) mediates cyclin D1 and p21 expression by regaining H3K9me3^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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