PF 1022A

133413-70-4

C52H76N4O12

DMSO : >= 43 mg/mL (45.30 mM)

Anti-infection

PF 1022A is a N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties; acts as an ionophore. IC50 value: Target: PF 1022A showed strong anthelmintic activities against Ascaridia galli in chickens [1]. PF1022A is a novel anthelmintic that binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF1022A binds to GABA receptors, which might contribute to the anthelmintic effect. Like other cyclodepsipeptides, PF1022A acts as an ionophore [2]. In vitro, PF1022A showed low activity on embryonation but significantly inhibited egg hatch (10 and 100 ug/ml), whereas albendazole (10 and 100 ug/ml) revealed statistically significant inhibitions of both embryonation and egg hatch. PF1022A (1-100 ug/ml) completely inhibited larval movement at most examination points [3].