Comparison

CUDC-427

Item no. CS-3392-10mg
Manufacturer ChemScene
Amount 10mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 1446182-94-0
Available
Alternative Names
GDC-0917
CAS
1446182-94-0
Purity
>98%
Formula
C29H36N6O4S
MWt
564.70
Solubility
DMSO : >= 61 mg/mL (108.02 mM)
Clinical Information
Phase 1
Pathway
Apoptosis
Target
IAP
Biological Activity
CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. In Vitro: GDC-0917 (0.1 nM-10 uM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 uM (56.5 ng/mL)[1]. In Vivo: GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10mg
Available: In stock
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