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Mps1-IN-3

Mps1-IN-3

Item no.	CS-3412-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Oncology By Cell Type Blastoma Carcinoma Mesothelioma Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1609584-72-6
Available
CAS	1609584-72-6
Purity	>98%
Formula	C26H31N7O4S
MWt	537.63
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Target	Mps1; Mps1
Biological Activity	Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC₅₀ of 50 nM. IC50 & Target: IC50: 50 nM (MPS1)^[1] In Vitro: Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC₅₀ of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC₅₀ of appr 5 uM. Mps1-IN-3 (2 uM) can completely abrogates checkpoint^[1]. In Vivo: Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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