DPN

1428-67-7

239.27

DMSO : 100 mg/mL (417.94 mM; Need ultrasonic); H2O : 0.67 mg/mL (2.80 mM; Need ultrasonic)

Others

DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor beta (ERbeta) selective ligand, with an EC₅₀ of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases^[1][2]. In Vitro: DPN has a 70-fold ERalpha relative binding affinity selectivity, and it is a full ERalpha agonist with a 78-fold ERalpha potency selectivity (EC₅₀=0.85 nM for ERbeta; EC₅₀=66 nM for ERalpha)^[1].
DPN (10 nM) prevents morphological alterations from Abeta_1-42 (10 uM)-induced toxicity in cultured cortical neurons^[2].
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner^[2].
DPN (0.1-100 nM) significantly reduces Abeta_1-42-stimulated expression of Bax in a non-dose dependent manner^[2].
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Abeta_1-42 treatment on cultured cortical neurons^[2].
DPN (0.1-100 nM) suppresses the Abeta_1-42-upregulated phosphorylation of JNK and p38^[2].
In Vivo: DPN (10 ug; s.c.; daily, for 11 days) increases swimming and decreased immobility in the FST and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model^[3].