MDK83190

79183-19-0

C15H9Cl2NO2

DMSO : >= 46 mg/mL (150.26 mM)

Apoptosis

MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner^[1]. IC50 & Target: IC50: 4-9 uM (Leukemia origin cells)^[1]. In Vitro: MDK83190 (Compound 2) (1-50 uM; 2 hours) effects against cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) with IC₅₀ values ranging from 4 to 9 uM^[1].
MDK83190 (Compound 2) (20 uM; 30 mins) activates procaspase-9 and procaspase-3 in a cyto c-dependent manner^[1].
MDK83190 (Compound 2) (0.1-100 uM; 22 hours) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, and finally killing cells with an IC₅₀ of 4 uM^[1].