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Nepicastat (hydrochloride)

Nepicastat (hydrochloride)

Item no.	CS-3559-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	170151-24-3
Available
Alternative Names	SYN-117 hydrochloride; RS-25560-197 hydrochloride
CAS	170151-24-3
Purity	>98%
Formula	C14H16ClF2N3S
MWt	331.81
Solubility	DMSO : 6 mg/mL (18.08 mM; Need ultrasonic); H2O : 2 mg/mL (6.03 mM; Need ultrasonic and warming)
Clinical Information	Phase 2
Pathway	Metabolic Enzyme/Protease
Target	Dopamine beta-hydroxylase
Biological Activity	Nepicastat hydrochloride (SYN-117 hydrochloride; RS-25560-197 hydrochloride) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 +/- 0.8 and 9.0 +/- 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase) Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.

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