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Naspm (trihydrochloride)

Naspm (trihydrochloride)

Item no.	CS-3630-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1049731-36-3
Available
Alternative Names	1-Naphthylacetyl spermine trihydrochloride
CAS	1049731-36-3
Purity	>98%
Formula	C22H37Cl3N4O
MWt	479.91
Solubility	DMSO : 6.4 mg/mL (13.34 mM; Need ultrasonic); H2O : 50 mg/mL (104.19 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Target	iGluR; iGluR
Biological Activity	Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. In Vitro: NASPM selectively suppresses the inwardly rectifying and Ca²⁺-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC₅₀ value of 0.33 uM. The blocking effect of NASPM on the Ca²⁺-permeable AMPA receptors is use and voltage-dependent^[1].

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