Baohuoside I

113558-15-9

C27H30O10

DMSO : >= 32 mg/mL (62.19 mM)

Apoptosis; GPCR/G Protein; Immunology/Inflammation

Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity. IC50 & Target: CXCR4^[1] In Vitro: Baohuoside I is an inhibitor of CXCR4, and downregulates CXCR4 expression at 12-25 uM. Baohuoside I (0-25 uM) suppresses NF-kappaB activation in a dose-dependent manner, suppresses CXCL12 induced the invasion of cervical cancer cells. Baohuoside I also inhibits invasion of breast cancer cells^[1]. Baohuoside I inhibits A549 cell viability, with IC₅₀s of 25.1 uM at 24 h, 11.5 uM and 9.6 uM at 48 h and 72 h, respectively. Baohuoside I ((25 uM) suppresses the caspase cascade in A549 cells, elevates ROS levels and activates JNK and p38^MAPK signaling cascade^[2]. Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 ug/mL) significantly and dose-dependently blocks the growth of esophageal squamous cell carcinoma Eca109 cells, with an IC₅₀ of 4.8 ug/mL at 48 h^[3]. In Vivo: Baohuoside I (25 mg/kg) decreases beta-catenin protein levels, cyclin D1 and survivin expression in nude mice^[3].