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Pyridostatin (hydrochloride)

Pyridostatin (hydrochloride)

Item no.	CS-3851-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1781882-65-2
Available
Alternative Names	RR-82 hydrochloride
CAS	1781882-65-2
Purity	>98%
Formula	C31H37Cl5N8O5
MWt	778.94
Solubility	H2O : >= 31 mg/mL (39.80 mM)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage
Target	G-quadruplex
Biological Activity	Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a K_d of 490 nM. IC50 & Target: Kd: 490 nM (G-quadruplexe)^[1] In Vitro: Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a K_d of 490 nM^[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 uM, causes DNA double-strand breaks (DSBs) at 1 uM, downregulates BRCA1 in neurons at 1, 2 or 5 uM^[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes^[3].

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Amount: 50mg

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