NMS-859

1449236-96-7

C15H12ClN3O3S

DMSO : >= 42 mg/mL (120.07 mM)

Cell Cycle/DNA Damage

NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC₅₀s of 0.37 and 0.36 uM for wild-type VCP in the presence of 60 uM and 1 mM ATP in cells, respectively. IC50 & Target: IC50: 360 nM (Cellular p97, 1 mM ATP), 370 nM (Cellular p97, 60 uM ATP)^[1] In Vitro: NMS-859 is a potent VCP inhibitor, with IC₅₀s of 0.37 and 0.36 uM for wild-type VCP in the presence of 60 uM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCP^C522T. NMS-859 also suppresses the proliferation of cells, with IC₅₀s of 3.5 uM and 3.0 uM in HCT116 and HeLa cell lines, respectively^[1].