Comparison

Wogonin

Item no. CS-3959-5mg
Manufacturer ChemScene
Amount 5mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 632-85-9
Available
CAS
632-85-9
Purity
>98%
Formula
C16H12O5
MWt
284.26
Solubility
DMSO : >= 48 mg/mL (168.86 mM)
Clinical Information
No Development Reported
Pathway
Cell Cycle/DNA Damage; Autophagy; Stem Cell/Wnt
Target
CDK; Autophagy; Wnt
Biological Activity
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects. IC50 & Target: CDK8, Wnt[1], CDK4[2] In Vitro: Wogonin (0-200 uM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 uM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits beta-catenin-mediated transcription through suppressing the activity of CDK8[1]. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 uM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells[2]. Wogonin (1.25, 2.5, 5, 10, 20 ug/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells[3]. In Vivo: Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model[1]. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-gamma expression in mice with ALD and EtOH induced RAW264.7 cells[3].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5mg
Available: In stock
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