Mirk-IN-1

1386979-55-0

C23H17Cl2N5O4

DMSO : 5 mg/mL (10.03 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)

Protein Tyrosine Kinase/RTK

Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68+/-48 nM and 22+/-8 nM respectively. IC50 value: 68+/-48/22+/-8 nM (Dyrk1B/Dyrk1A) [1] Target: Dyrk inhibitor Mirk-IN-1 had an EC50 of 1.9 +/-0.2 mmol/L on SW620 cells. At a much higher concentration of 10 mmol/L in a kinase assay, Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by 88%, 64%, 56%, and 73%, respectively [1]. Mirk-IN-1 was able to block tumor cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2].