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p38 MAPK-IN-1

p38 MAPK-IN-1

Item no.	CS-4225-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Oncology Neuroscience Neural Signaling By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1006378-90-0
Similar products	1006378-90-0
Available
CAS	1006378-90-0
Purity	>98%
MWt	349.35
Formula	C21H15F2N2O
Solubility	DMSO : 8.33 mg/mL (23.84 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	MAPK/ERK Pathway; Autophagy
Target	p38 MAPK; Autophagy
Biological Activity	p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC₅₀ of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability. In Vivo: p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t_1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a C_max of 5.3 uM for po in male wistar rats^[1]. p38 MAPK-IN-1 dose-dependently inhibits TNFalpha production with an ED₅₀ of 0.5 mg/kg^[1].
Research Area	Inflammation/Immunology

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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