TH588

Item no.	CS-4507-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1609960-31-7
Available
CAS	1609960-31-7
Purity	>98%
Formula	C13H12Cl2N4
MWt	295.17
Solubility	DMSO : 16 mg/mL (54.21 mM; Need ultrasonic and warming)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage
Target	DNA/RNA Synthesis
Biological Activity	TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC₅₀= 5 nM). IC50 & Target: IC50: 5 nM (MTH1)^[1] In Vitro: TH588 (2-10uM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC₅₀s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 uM^[1]. In Vivo: TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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