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Quetiapine sulfoxide (dihydrochloride)

Quetiapine sulfoxide (dihydrochloride)

Item no.	CS-5189-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	329218-11-3
Similar products	329218-11-3
Available
Alternative Names	Quetiapine S-oxide dihydrochloride
CAS	329218-11-3
Purity	>98%
MWt	472.43
Formula	C21H27Cl2N3O3S
Solubility	H2O : 250 mg/mL (529.18 mM; Need ultrasonic)
Clinical Information	Launched
Pathway	Metabolic Enzyme/Protease
Target	Drug Metabolite
Biological Activity	Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic^[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist^[2]. In Vivo: The C_max value (mean+/-SD) is estimated for Quetiapine sulfoxide (77.3+/-32.4 ng/mL). The AUC_last value is estimated for Quetiapine sulfoxide (1, 286+/-458 ng-h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing^[1].
Research Area	Neurological Disease

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