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PRE-084 (hydrochloride)

PRE-084 (hydrochloride)

Item no.	CS-5241-200mg
Manufacturer	ChemScene
Amount	200mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	75136-54-8
Similar products	75136-54-8
Available
CAS	75136-54-8
Purity	>98%
MWt	353.88
Formula	C19H28ClNO3
Solubility	DMSO : >= 34 mg/mL (96.08 mM)
Clinical Information	No Development Reported
Pathway	Neuronal Signaling; GPCR/G Protein
Target	Sigma Receptor; Sigma Receptor
Biological Activity	PRE-084 hydrochloride is a high affinity, selective sigma1 agonist, has an IC50 of 44 nM in the sigma receptor assay. IC50 value: 44 nM Target: sigma receptor in vitro: PRE-084 has an IC50 of more than 100, 000 nM for PCP receptors and an IC50 higher than 10, 000 nM in a variety of other receptor systems. [1] in vivo: PRE-084 improves motor neuron survival and motor performance in wobbler mice. PRE-084 enhances BDNF-mediated trophic support.[2]
Research Area	Neurological Disease

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Amount: 200mg

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