Comparison

Mavoglurant

Item no. CS-5245-100mg
Manufacturer ChemScene
Amount 100mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 543906-09-8
Available
Alternative Names
AFQ056
CAS
543906-09-8
Purity
>98%
Formula
C19H23NO3
MWt
313.39
Solubility
DMSO : >= 47 mg/mL (149.97 mM)
Clinical Information
Phase 3
Pathway
GPCR/G Protein; Neuronal Signaling
Target
mGluR; mGluR
Biological Activity
Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. IC50 value: 30 nM Target: mGluR5 in vitro: Mavoglurant is a selective non-competitive antagonist which showed efficacy in the treatment of L-dopa induced dyskinesias in Parkinson's disease and Fragile X mental retardation in proof of principle studies. Mavoglurant is selective over the other mGluR subtypes, iGluRs and a panel of 238 CNS relevant receptors, transporter or enzymes. [1] In vivo: Mavoglurant shows an improved pharmacokinetic profile in rat and efficacy in the stress-induced hyperthermia test in mice as compared to the prototypic mGluR5 antagonist MPEP.[1]

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100mg
Available: In stock
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