SKF 38393 (hydrochloride)

62717-42-4

C16H18ClNO2

DMSO : >= 34 mg/mL (116.53 mM)

GPCR/G Protein; Neuronal Signaling

SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM^[1]. IC50 & Target: IC50: 110 nM (D1DR) In Vitro: The selective D1-R agonist SKF-38393 (hydrochloride) induces a similar change in cytomorphology and increased the levels of media cAMP^[2].
SKF-38393 (hydrochloride) (10 umol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells^[2].
In Vivo: SKF-38393 (hydrochloride) (10 mg/kg; i.p.; every 16 hours) blocks the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) -induced depletion of glutathione^[3].
SKF-38393 (hydrochloride) attenuates MPTP-induced depletion of dopamine^[3].
SKF-38393 (hydrochloride) enhances the activity of superoxide dismutase and hence mimics the action of Selegiline^[3].
SKF-38393 (hydrochloride) enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action^[4].