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Orexin 2 Receptor Agonist

Orexin 2 Receptor Agonist

Item no.	CS-5456-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Metabolism Glucose Homeostasis Regulation of Appetite Obesity Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1796565-52-0
Available
CAS	1796565-52-0
Purity	>98%
Formula	C32H34N4O5S
MWt	586.70
Solubility	DMSO : >= 32 mg/mL (54.54 mM)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein; Neuronal Signaling
Target	Orexin Receptor (OX Receptor); Orexin Receptor (OX Receptor)
Biological Activity	Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist. IC50 value: 23 nM (EC50) Target: Orexin 2 Receptor Orexin 2 Receptor Agonist shows not only potent activity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 uM, respectively.[1]

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Amount: 100mg

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